Bias in causal comparisons has a direct correspondence with distributional imbalance of covariates between treatment groups. Weighting strategies such as inverse propensity score weighting attempt to mitigate bias by either modeling the treatment assignment mechanism or balancing specified covariate moments. This paper introduces a new weighting method, called energy balancing, which instead aims to balance weighted covariate distributions. By directly targeting distributional imbalance, the proposed weighting strategy can be flexibly utilized in a wide variety of causal analyses, including the estimation of average treatment effects and individualized treatment rules. Our energy balancing weights (EBW) approach has several advantages over existing weighting techniques. First, it offers a model-free and robust approach for obtaining covariate balance that does not require tuning parameters, obviating the need for modeling decisions of secondary nature to the scientific question at hand. Second, since this approach is based on a genuine measure of distributional balance, it provides a means for assessing the balance induced by a given set of weights for a given dataset. Finally, the proposed method is computationally efficient and has desirable theoretical guarantees under mild conditions. We demonstrate the effectiveness of this EBW approach in a suite of simulation experiments, and in studies on the safety of right heart catheterization and the effect of indwelling arterial catheters.
翻译:在因果比较中,“因果比较”与治疗群体之间共变分布不平衡有直接的对应关系; 加权战略,例如逆向偏差评分加权法,试图通过模拟治疗分配机制或平衡特定共变时间来减轻偏差; 本文采用一种新的加权方法,称为能源平衡,目的是平衡加权共变分布; 直接针对分配不平衡,拟议的加权战略可以在广泛的各种因果分析中灵活使用,包括估计平均治疗效果和个别治疗规则; 我们的能源平衡权重(EBW)方法比现有的加权技术具有若干优势。 首先,它为获得不需调整参数的共变平衡提供了无损和稳健健的模型方法,从而避免了将次要决定建模与手头的科学问题挂钩的必要性。 其次,由于这一方法以真正衡量分配平衡为基础,因此可以灵活地利用这一方法来评估特定数据集特定一组重量所引发的平衡。 最后,拟议的方法在较温条件下是高效和有可取的理论保证。 我们用EBW方法在试验中展示了EB-W系统安全性试验和CA级试验的效果。