Improving instrumental variable estimators with post-stratification

An instrumental variable (IV) is a device that encourages units in a study to be exposed to a treatment. Under a set of key assumptions, a valid instrument allows for consistent estimation of treatment effects for compliers (those who are only exposed to treatment when encouraged to do so) even in the presence of unobserved confounders. Unfortunately, popular IV estimators can be unstable in studies with a small fraction of compliers. Here, we explore post-stratifying the data using variables that predict complier status (and, potentially, the outcome) to yield better estimation and inferential properties. We outline an estimator that is a weighted average of IV estimates within each stratum, weighing the stratum estimates by their estimated proportion of compliers. We then explore the benefits of post-stratification in terms of bias reduction, variance reduction, and improved standard error estimates, providing derivations that identify the direction of bias as a function of the relative means of the compliers and non-compliers. We also provide a finite-sample asymptotic formula for the variance of the post-stratified estimators. We demonstrate the relative performances of different IV approaches in simulations studies and discuss the advantages of our design-based post-stratification approach over incorporating compliance-predictive covariates into two-stage least squares regressions. In the end, we show covariates predictive of outcome can increase precision, but only if one is willing to make a bias-variance trade-off by down-weighting or dropping those strata with few compliers. Our methods are further exemplified in an application.