Fluid-structure interactions are central to many bio-molecular processes, and they impose a great challenge for computational and modeling methods. In this paper, we consider the immersed boundary method (IBM) for biofluid systems, and to alleviate the computational cost, we apply reduced-order techniques to eliminate the degrees of freedom associated with a large number of fluid variables. We show how reduced models can be derived using Petrov-Galerkin projection and subspaces that maintain the incompressibility condition. More importantly, the reduced-order model is shown to preserve the Lyapunov stability. We also address the practical issue of computing coefficient matrices in the reduced-order model using an interpolation technique. The efficiency and robustness of the proposed formulation are examined with test examples from various applications.
翻译:流体结构相互作用是许多生物分子过程的核心,对计算和建模方法构成巨大的挑战。在本文件中,我们考虑了生物流体系统浸入的边界法(IBM),并且为了降低计算成本,我们运用了减序技术来消除与大量流体变量相关的自由度。我们用Petrov-Galerkin投影和保持不压缩状态的子空间来显示如何减少模型。更重要的是,减序模型是为了维护Lyapunov的稳定。我们还用一种内推法来解决减序模型中计算系数矩阵的实际问题。我们用各种应用的试验实例来审查拟议公式的效率和稳健性。