This paper presents a novel approach that integrates 5G Time of Arrival (ToA) measurements into ORB-SLAM3 to enable global localization and enhance mapping capabilities for indoor drone navigation. We extend ORB-SLAM3's optimization pipeline to jointly process ToA data from 5G base stations alongside visual and inertial measurements while estimating system biases. This integration transforms the inherently local SLAM estimates into globally referenced trajectories and effectively resolves scale ambiguity in monocular configurations. Our method is evaluated using five real-world indoor datasets collected with RGB-D cameras and inertial measurement units (IMUs), complemented by simulated 5G ToA measurements at 28 GHz and 78 GHz frequencies using MATLAB and QuaDRiGa. Extensive experiments across four SLAM configurations (RGB-D, RGB-D-Inertial, Monocular, and Monocular-Inertial) demonstrate that ToA integration enables consistent global positioning across all modes while significantly improving local accuracy in minimal sensor setups. Notably, ToA-enhanced monocular SLAM achieves superior local accuracy (6.3 cm average) compared to the RGB-D baseline (11.5 cm), and enables reliable operation of monocular-inertial SLAM in scenarios where the baseline system fails completely. While ToA integration offers limited local accuracy improvements for sensor-rich configurations like RGB-D SLAM, it consistently enables robust global localization.
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