The Exchangeability Assumption for Permutation Tests of Multiple Regression Models: Implications for Statistics and Data Science

Permutation tests are a powerful and flexible approach to inference via resampling. As computational methods become more ubiquitous in the statistics curriculum, use of permutation tests has become more tractable. At the heart of the permutation approach is the exchangeability assumption, which determines the appropriate null sampling distribution. We explore the exchangeability assumption in the context of permutation tests for multiple linear regression models. Various permutation schemes for the multiple linear regression setting have been previously proposed and assessed in the literature. As has been demonstrated previously, in most settings, the choice of how to permute a multiple linear regression model does not materially change inferential conclusions. Regardless, we believe that (1) understanding exchangeability in the multiple linear regression setting and also (2) how it relates to the null hypothesis of interest is valuable. We also briefly explore model settings beyond multiple linear regression (e.g., settings where clustering or hierarchical relationships exist) as a motivation for the benefit and flexibility of permutation tests. We close with pedagogical recommendations for instructors who want to bring multiple linear regression permutation inference into their classroom as a way to deepen student understanding of resampling-based inference.