Quantifying the effect of uncertainties in systems where only point evaluations in the stochastic domain but no regularity conditions are available is limited to sampling-based techniques. This work presents an adaptive sequential stratification estimation method that uses Latin Hypercube Sampling within each stratum. The adaptation is achieved through a sequential hierarchical refinement of the stratification, guided by previous estimators using local (i.e., stratum-dependent) variability indicators based on generalized polynomial chaos expansions and Sobol decompositions. For a given total number of samples $N$, the corresponding hierarchically constructed sequence of Stratified Sampling estimators combined with Latin Hypercube sampling is adequately averaged to provide a final estimator with reduced variance. Numerical experiments illustrate the procedure's efficiency, indicating that it can offer a variance decay proportional to $N^{-2}$ in some cases.
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