This paper presents a comparative analysis of structural seismic responses under two types of ground motion inputs: (i) synthetic motions generated by stochastic ground motion models and (ii) recorded motions from an earthquake database. Five key seismic response metrics - probability distributions, statistical moments, correlations, tail indices, and variance-based global sensitivity indices - are systematically evaluated for two archetypal structures: a 12-story medium-period building and a high-rise long-period tower. Both ground motion datasets are calibrated to a shared response spectrum, ensuring consistency in spectral characteristics, including spectral median, variance, and correlation structure. The analysis incorporates both aleatory uncertainties from ground motion variability and epistemic uncertainties associated with structural parameters, providing a comprehensive comparison of seismic responses. The results demonstrate close agreement in global response characteristics, including distributions, correlations, and sensitivity indices, between synthetic and recorded motions, with differences typically within 15\%. However, significant discrepancies are observed under extreme conditions, particularly in tail behavior, higher-order moments, and drift responses of long-period structures, with differences exceeding 50\%. These discrepancies are attributed to the non-Gaussian features and complex characteristics inherent in recorded motions, which are less pronounced in synthetic datasets. The findings support the use of synthetic ground motions for evaluating global seismic response characteristics, while highlighting their limitations in capturing rare-event behavior and long-period structural dynamics.
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