This letter proposes a Bayesian channel estimation method that leverages on the a priori information provided by the Electromagnetic Digital Twin's (EM-DT) representation of the environment. The proposed approach is compared with several conventional techniques in terms of Normalized Mean Square Error (NMSE), spectral efficiency, and number of pilots. Simulations prove more than $10\,$dB gain in NMSE and a spectral efficiency comparable to that of the ideal channel state information, for different signal-to-noise ratio (SNR) values. Additionally, the Bayesian EM-DT-empowered channel estimation enables a remarkable pilot reduction compared to maximum likelihood methods at low SNR.
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