诊治一体的胰腺癌整合素αvβ6靶向多功能分子探针

项目名称： 诊治一体的胰腺癌整合素αvβ6靶向多功能分子探针

项目编号： No.81471712

项目类型： 面上项目

立项/批准年度： 2015

项目学科： 医药、卫生

项目作者： 刘昭飞

作者单位： 北京大学

项目金额： 73万元

中文摘要： 早期精确诊断对恶性肿瘤如胰腺癌的治疗和预后具有重要意义。核医学和分子影像学的迅速发展为肿瘤的早期诊断和合理治疗提供了重要的手段。分子影像依赖于高灵敏和高特异性的分子探针。最近几年，整合素αvβ6在肿瘤发生、发展过程中的重要作用逐渐被认识。然而，以整合素αvβ6为靶点的分子影像学研究报道较少。本研究拟以整合素αvβ6为靶点，设计构建肿瘤特异性的多功能、多模态环肽分子探针，探讨其在胰腺癌动物模型中的显像和治疗作用。本研究对于建立新型有效的肿瘤整合素αvβ6分子影像方法、监测恶性肿瘤进展、早期评价抗肿瘤药物治疗疗效具有独特意义；本研究关于多功能分子探针用于肿瘤靶向治疗的探索可能为常规治疗无效的肿瘤提供新的、有效的治疗策略和手段。

中文关键词： 分子影像；分子探针；放射性核素；肿瘤靶向；胰腺癌

英文摘要： Early and accurate diagnosis has great significance for the efficient treatment and better prognosis of malignant tumors (e.g., pancreatic cancer). Nuclear medicine/molecular imaging, a rapidly developing research field, provides a powerful tool for the early diagnosis and better management of tumors. Molecular imaging relies on high sensitive and high specific molecular probes. Recent years, the pivotal role of integrin αvβ6 in tumor growth and development has been recognized. However, so far studies regarding integrin αvβ6-targeted molecular imaging are rare. In this project, we propose to design and synthesize an integrin αvβ6-tageted multifunctional molecular probe, and investigate whether it can be used for pancreatic cancer imaging and therapy in animal models. This study would provide a novel and powerful approach for noninvasive imaging of tumor integrin αvβ6 expression, monitoring tumor growth, and earlier efficacy evaluation of anti-tumor drugs. This study would also develop a new strategy for the effective treatment of tumors that are resistant to conventional therapy.

英文关键词： Molecular imaging;Molecular probe;Radionuclide;Tumor targeting;Pancreatic cancer