核酸适配体修饰的磁性介孔氧化硅复合纳米材料的制备及在非水溶性抗癌药物靶向输运中的应用

项目名称： 核酸适配体修饰的磁性介孔氧化硅复合纳米材料的制备及在非水溶性抗癌药物靶向输运中的应用

项目编号： No.21201133

项目类型： 青年科学基金项目

立项/批准年度： 2013

项目学科： 无机化学

项目作者： 袁荃

作者单位： 武汉大学

项目金额： 25万元

中文摘要： 低水溶性是很多抗癌药物的本征性质，这一缺点阻碍了其活性成分临床应用的效果。此外，由于抗癌药物在癌症细胞和正常组织中存在非特异性生物分布，对易于迅速增殖的细胞容易引起毒性。介孔氧化硅稳定的多孔结构、无生物毒性、大的表面积和可调的孔径，使得这类材料成为药物输运，特别是非水溶性药物输运载体的最佳选择。核酸适配体是近年发展起来的新型识别分子，折叠形成特定三维结构与生物靶标高亲和力和高特异性结合，与抗体相比有自身的很多优势。本项目提出了一种核酸适配体功能化的磁性介孔氧化硅纳米粒子构建的药物载体的设计和制备，通过结合核酸适配体对癌细胞的靶向功能和介孔氧化硅对疏水性抗癌药物的载带功能，获得用于非水溶性抗癌药物靶向输运和可控释放的纳米器件。项目将对这种非水溶性抗癌药物靶向输运器件的制备技术、靶向输运药物、药物控制释放动力学等开展深入系统的研究，为基于介孔氧化硅的纳米生物医学功能器件的开发打下基础。

中文关键词： 核酸适配体；疾病诊疗；无机功能材料；；

英文摘要： Low solubility in water is an intrinsic property of many anticancer drugs, which hinders the clinical use of those active ingredients. In addition, due to the nonspecific biodistribution of the drug in both cancer cells and normal tissues, anticancer drugs have been associated with significant toxicities to rapidly proliferating cells, such as nephrotoxicity and neurotoxicity. Targeted drug delivery is a method of delivering drug in a manner that increases the concentration of the medication in some parts of the body relative to others. For an effective drug delivery device, it is important to release the medication only under defined conditions, e.g. upon entrance into a cancer cell. The synthesis of such valves has become an interesting and widely investigated field of research. The features of mesoporous silica such as stable mesostructures, lack of cytotoxicity, large surface areas and tailorable pore sizes, make them excellent candidates for drug delivery and especially for delivery of hydrophobic agents. Aptamers are the synthetic DNA-based equivalent of antibodies and have unique molecular recognition properties, and improved stability. The construction of a drug carrier based on aptamer-modified mesoporous nanoparticles will provide a new opportunity to achieve targeted delivery and release of hydrophobi

英文关键词： Aptamer；Disease diagnosis/treatment；Inorganic functional materials；；