氧化石墨烯/光敏剂复合纳米材料的自组装、高效光动力治疗及机理研究

项目名称： 氧化石墨烯/光敏剂复合纳米材料的自组装、高效光动力治疗及机理研究

项目编号： No.21473153

项目类型： 面上项目

立项/批准年度： 2015

项目学科： 数理科学和化学

项目作者： 焦体峰

作者单位： 燕山大学

项目金额： 80万元

中文摘要： 氧化石墨烯，作为新型碳质材料表现出许多奇特而优异的性能和独特的纳米结构，成为近年来国内外科学家关注研究的焦点。光动力疗法是以光、光敏剂和氧的相互作用为基础的一种新的非侵入性治疗癌症/非癌症疾病的手段。本项目拟制备若干作为光敏剂药物载体的氧化石墨烯复合纳米材料，探索多种因素在有序组装过程中的贡献和影响，揭示组装单元的结构与性质、微纳米的结构及担载光敏剂之间的构效关系。同时重点研究复合材料作为药物载体对若干光敏剂的自组装过程以及生物体系中光动力治疗性能及机理研究，摸索剂型设计及规模化制备技术，构建灵敏高效选择性好的新型光动力治疗药物。新型高效光敏剂药物载体氧化石墨烯复合材料的自组装、光动力治疗及机理研究，将拓展石墨烯复合材料的研究领域，构建基于石墨烯有序组装体的新型光动力治疗药物，对化学、医药、材料等领域相关研究工作具有重要的科学意义和潜在的应用价值。

中文关键词： 自组装；复合纳米材料；氧化石墨烯；光动力治疗；光敏剂

英文摘要： Graphene oxide, as a new carbon material, exhibits many novel and excellent performances and unique nanostructures, which become the research focus of scientists at different countries in recent years. Photodynamic therapy, based on the interaction of light, photosensitizer and oxygen, are a kind of new non-invasive treatments of cancer/non-cancer diseases. The present project is aimed to prepare some series of graphene oxide composite nanomaterials as drug carriers of photosensitizer, to explore the contribution and influence of variety of factors in orderly assembly process, and to reveal the relationships between structure and nature of the assembly unit, micro/nanostructures and photosensitizer composite. At the same time, present researches focus on the self-assembly process of the composites as drug carriers for photosensitizers and properties/mechanisms of photodynamic therapy in some biological systems. In the study, large-scale preparation technology and the dosage design should be also finally explored, in order to build sensitive and efficient high-selective drug of photodynamic therapy. Novel self-assembly and the mechanism of photodynamic therapy based on graphene oxide-photosensitizer composite drugs would broaden the research fields of graphene composites nanomaterials, construct novel photodynamic therapy drugs based on ordered graphene assembly, showing important significance and potential applications in the fields of the chemicals, pharmacochemistry, and materials science.

英文关键词： self-assembly;composite nanomaterials;graphene oxide;photodynamic therapy;photosensitizers