基于硼酸化的纳米材料分子印迹电化学传感器构筑及其对生物分子双识别研究

项目名称： 基于硼酸化的纳米材料分子印迹电化学传感器构筑及其对生物分子双识别研究

项目编号： No.21275055

项目类型： 面上项目

立项/批准年度： 2013

项目学科： 数理科学和化学

项目作者： 施国跃

作者单位： 华东师范大学

项目金额： 80万元

中文摘要： 生命科学研究中，对生命信息分子的选择性识别成为准确获取生命过程中的化学与生物信息并阐释生命活动机理的核心问题。本项目拟通过将纳米材料表面的有机硼酸类化合物功能化和表面分子印迹技术两者相结合，努力开展具有双识别作用的特异性功能化纳米材料的研究和应用，寻找适合于生命科学领域的分析方法新原理、新技术。我们将以氧化石墨烯等纳米材料为平台，以多巴胺为目标分子，在纳米材料表面首先进行硼酸功能化，然后进行表面分子印迹制备特异性双识别复合材料；通过分子印迹在结构上的单体识别基团以及硼酸基团的功能化识别，实现对生物分子的高效率、高特异性双识别检测；从理论上研究纳米材料表面硼酸化和分子印迹的双识别机理，为系统性分子识别材料的研制提供一个科学的模型和坚实的理论基础；同时探索具有特异性多识别功能的新型材料的研制和应用，为寻找更多适合生命信息分子如蛋白质、核酸、多肽等特异性、敏感性的检出方法提供重要、有效的途径。

中文关键词： 分子识别；分子印迹聚合物；硼酸功能化；纳米材料；传感器

英文摘要： In the research of life science, the recognition of molecule, which contains life message, is the main problem in getting the chemical, biological information from life process and interpreting life activities.The project is proposed to combine boronic acid-functionalized with surface molecular imprinting technology, to study and apply the double recognition nanomaterials with high selectivicity and to find new principles and technology to serve the field of life science. The nanomaterials are boronic acid functionalized at first and then the double recognition composites are synthesized through surface molecular imprinting technology based on the nanomaterials such as graphene oxide as the platform and dopamine as the target molecule. Through the monomer recognition groups and specific combination between boronic acid groups and hydroxyl compounds, we can detect the biological molecule more efficiently and selectively. We will also do some research on double recognition based on boronic acid functionalization and molecular imprinting technology theoretically to provide a scientific model and a solid theoretical foundation for the study of molecular recognition materials. Meanwhile, we try to explore novel, double recognition materials and its preparation and application, in order to provide an important and eff

英文关键词： Molecular recognition；Molecular imprinting polymer；Boronic acid functionalization；Nanomaterial；Sensor