Quantum relative entropy programs are convex optimization problems which minimize a linear functional over an affine section of the epigraph of the quantum relative entropy function. Recently, the self-concordance of a natural barrier function was proved for this set. This has opened up the opportunity to use interior-point methods for nonsymmetric cone programs to solve these optimization problems. In this paper, we show how common structures arising from applications in quantum information theory can be exploited to improve the efficiency of solving quantum relative entropy programs using interior-point methods. First, we show that the natural barrier function for the epigraph of the quantum relative entropy composed with positive linear operators is optimally self-concordant, even when these linear operators map to singular matrices. Second, we show how we can exploit a catalogue of common structures in these linear operators to compute the inverse Hessian products of the barrier function more efficiently. This step is typically the bottleneck when solving quantum relative entropy programs using interior-point methods, and therefore improving the efficiency of this step can significantly improve the computational performance of the algorithm. We demonstrate how these methods can be applied to important applications in quantum information theory, including quantum key distribution, quantum rate-distortion, quantum channel capacities, and estimating the ground state energy of Hamiltonians. Our numerical results show that these techniques improve computation times by up to several orders of magnitude, and allow previously intractable problems to be solved.
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