We extend the unstructured homogeneously mixing epidemic model introduced by Lamprinakou et al. [arXiv:2208.07340] considering a finite population stratified by age bands. We model the actual unobserved infections using a latent marked Hawkes process and the reported aggregated infections as random quantities driven by the underlying Hawkes process. We apply a Kernel Density Particle Filter (KDPF) to infer the marked counting process, the instantaneous reproduction number for each age group and forecast the epidemic's future trajectory in the near future; considering the age bands and the population size does not increase the computational effort. We demonstrate the performance of the proposed inference algorithm on synthetic data sets and COVID-19 reported cases in various local authorities in the UK. We illustrate that taking into account the individual heterogeneity in age decreases the uncertainty of estimates and provides a real-time measurement of interventions and behavioural changes.
翻译:我们推广了Lamprinakou等人[arXiv:2208.07.340]提出的非结构化同质混合的流行病模式,考虑到按年龄组划分的有限人口,我们用隐性标记霍克斯过程和报告的累计感染作为随机数量的模型,由基本霍克斯过程驱动,我们采用内核密度粒子过滤法(KDPF)来推断标记的计数过程、每个年龄组的瞬时生殖数,并预测该流行病的近期发展轨迹;考虑到年龄波段和人口规模不会增加计算努力;我们展示了拟议合成数据集推算算算算法和英国各地方当局COVID-19报告案例的性能;我们说明,考虑到年龄上的个别异质性会降低估计数的不确定性,并对干预措施和行为变化进行实时衡量。