Facial action unit (AU) detection has long encountered the challenge of detecting subtle feature differences when AUs activate. Existing methods often rely on encoding pixel-level information of AUs, which not only encodes additional redundant information but also leads to increased model complexity and limited generalizability. Additionally, the accuracy of AU detection is negatively impacted by the class imbalance issue of each AU type, and the presence of noisy and false AU labels. In this paper, we introduce a novel contrastive learning framework aimed for AU detection that incorporates both self-supervised and supervised signals, thereby enhancing the learning of discriminative features for accurate AU detection. To tackle the class imbalance issue, we employ a negative sample re-weighting strategy that adjusts the step size of updating parameters for minority and majority class samples. Moreover, to address the challenges posed by noisy and false AU labels, we employ a sampling technique that encompasses three distinct types of positive sample pairs. This enables us to inject self-supervised signals into the supervised signal, effectively mitigating the adverse effects of noisy labels. Our experimental assessments, conducted on four widely-utilized benchmark datasets (BP4D, DISFA, GFT and Aff-Wild2), underscore the superior performance of our approach compared to state-of-the-art methods of AU detection. Our code is available at \url{https://github.com/Ziqiao-Shang/AUNCE}.
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