We discuss the recent paper on "excursion effect" by T. Qian et al. (2020). We show that the methods presented have close relationships to others in the literature, in particular to a series of papers by Robins, Hern\'{a}n and collaborators on analyzing observational studies as a series of randomized trials. There is also a close relationship to the history-restricted and the history-adjusted marginal structural models (MSM). Important differences and their methodological implications are clarified. We also demonstrate that the excursion effect can depend on the design and discuss its suitability for modifying the treatment protocol.
翻译:我们讨论了T. Qian等人(2020年)最近发表的关于“外泄效应”的文件,我们表明,所提出的方法与文献中的其他方法有密切关系,特别是与Robins、Hern\'{a}n和协作者关于将观察研究分析成一系列随机试验的一系列文件,也与历史限制和历史调整的边际结构模型(MSM)有密切关系。澄清了重要的差异及其方法影响。我们还表明,外泄效应可能取决于设计,并讨论其是否适合修改治疗协议。