Missing data are inevitable in longitudinal studies. Traditional methods, such as the full information maximum likelihood (FIML), are commonly used to handle ignorable missing data. However, they may lead to biased model estimation due to missing not at random data that often appear in longitudinal studies. Recently, machine learning methods, such as random forests (RF) and K-nearest neighbors (KNN) imputation methods, have been proposed to cope with missing values. Although machine learning imputation methods have been gaining popularity, few studies have investigated the tenability and utility of these methods in longitudinal research. Through Monte Carlo simulations, this study evaluates and compares the performance of traditional and machine learning approaches (FIML, RF, and KNN) in growth curve modeling. The effects of sample size, the rate of missingness, and the missing data mechanism on model estimation are investigated. Results indicate that FIML is a better choice than the two machine learning imputation methods in terms of model estimation accuracy and efficiency.
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