We propose and investigate a hidden Markov model (HMM) for the analysis of aggregated, super-imposed two-state signal recordings. A major motivation for this work is that often these recordings cannot be observed individually but only their superposition. Among others, such models are in high demand for the understanding of cross-talk between ion channels, where each single channel might take two different states which cannot be measured separately. As an essential building block we introduce a parametrized vector norm dependent Markov chain model and characterize it in terms of permutation invariance as well as conditional independence. This leads to a hidden Markov chain "sum" process which can be used for analyzing aggregated two-state signal observations within a HMM. Additionally, we show that the model parameters of the vector norm dependent Markov chain are uniquely determined by the parameters of the "sum" process and are therefore identifiable. Finally, we provide algorithms to estimate the parameters and apply our methodology to real-world ion channel data measurements, where we show competitive gating.
翻译:我们建议并调查一个隐蔽的Markov模型(HMM),用于分析合并的、超硬的双状态信号记录。这项工作的一个主要动机是,这些记录往往无法单独观察到,而只是它们的叠加位置。除其他外,这些模型对于理解离子信道之间的交叉对话有着很高的需求,因为每个单一频道可能采用两个无法分别测量的不同状态。作为基本构件,我们引入了一种准美化的媒介规范依赖Markov链模型,并以变异性以及有条件的独立为特征。这导致一个隐藏的Markov链“总和”过程,可以用来分析HMM内部的两种状态的汇总信号观测。此外,我们显示,矢量规范依赖Markov链的模型参数由“总和”过程的参数决定,因此可以识别。最后,我们提供算法来估计参数,并将我们的方法应用于现实世界离子频道的数据测量,我们在那里显示竞争性的格。