Enhanced Histopathology Image Feature Extraction using EfficientNet with Dual Attention Mechanisms and CLAHE Preprocessing

Breast cancer diagnosis relies heavily on histopathology image classification. This study proposes a novel approach leveraging Hybrid EfficientNet models integrated with advanced attention mechanisms (CB and deformable attention) to enhance feature extraction and focus on relevant tissue regions. Evaluating on the BreakHis dataset across multiple magnification scales (40X, 100X, 200X, 400X), we achieve state-of-the-art performance with EfficientNetV2-XL and CB, reaching 98.96% accuracy and 98.31% F1-score at 400X. Integration of CLAHE preprocessing and optimized computational efficiency demonstrates suitability for real-time clinical deployment.