The vertical ground reaction force (vGRF) and its characteristic weight acceptance and push-off peaks measured during walking are important for gait and biomechanical analysis. Current wearable vGRF estimation methods suffer from drifting errors or low generalization performances, limiting their practical application. This paper proposes a novel method for reliably estimating vGRF and its characteristic peaks using data collected from the smart insole, including inertial measurement unit data and the newly introduced center of the pressed sensor data. These data were fused with machine learning algorithms including artificial neural networks, random forest regression, and bi-directional long-short-term memory. The proposed method outperformed the state-of-the-art methods with the root mean squared error, normalized root mean squared error, and correlation coefficient of 0.024 body weight (BW), 1.79% BW, and 0.997 in intra-participant testing, and 0.044 BW, 3.22% BW, and 0.991 in inter-participant testing, respectively. The difference between the reference and estimated weight acceptance and push-off peak values are 0.022 BW and 0.017 BW with a delay of 1.4% and 1.8% of the gait cycle for the intra-participant testing and 0.044 BW and 0.025 BW with a delay of 1.5% and 2.3% of the gait cycle for the inter-participant testing. The results indicate that the proposed vGRF estimation method has the potential to achieve accurate vGRF measurement during walking in free living environments.
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