基于数据挖掘的高血压肝火亢盛证的生物学机制研究

项目名称： 基于数据挖掘的高血压肝火亢盛证的生物学机制研究

项目编号： No.81503382

项目类型： 青年科学基金项目

立项/批准年度： 2016

项目学科： 医药、卫生

项目作者： 马雪玲

作者单位： 北京中医药大学

项目金额： 17万元

中文摘要： 肝火亢盛证是高血压早期最主要的证候之一，探究其生物学调控机制对于高血压的早期干预和靶器官的保护具有重要的基础和临床意义。课题组前期研究发现高血压肝火亢盛证病证结合动物模型存在RAAS系统激活、交感神经活性增强，表现出“高肾上腺素能特征”和多巴胺能亢进，以及氧化应激损伤和血管内皮功能障碍。我们认为，高血压肝火亢盛证的生物学机制可能是上述通路关键节点分子的相互作用。因此本项目拟借助高血压病证结合动物模型，采用互信息方法从上述通路中筛选与高血压肝火亢盛证密切相关的分子，采用图模型刻画相关分子间的因果关系，采用决策树构建高血压肝火亢盛证的识别模型，并通过清肝泻火对证方药的反证，验证高血压肝火亢盛证的关键调控分子及其相互作用，从系统分子层面阐明高血压肝火亢盛证的生物学调控机制，为高血压肝火亢盛证的客观化诊断及疗效评价提供依据，并对高血压的早期干预提出新的治疗思路和干预环节。

中文关键词： 原发性高血压；数据挖掘；生物学机制

英文摘要： Liver-fire hyperactivity syndrome is one of the main syndromes in early stage of hypertension, illustrate its biological mechanism has great significance in early intervention of hypertension and protection of other target organs. Our previous research found that activation of RAAS system and enhancement of sympathetic nervous activity occurred in hypertension with liver-fire hyperactivity syndrome combined animal models, with characteristics of high adrenergic and dopaminergic hyperthyroidism, oxidative damages and vascular endothelial dysfunction. The biological mechanism of hypertension liver-fire hyperactivity syndrome might be the key nodes' molecular interactions in the above pathways. In this project, we try to determine the key regulatory molecules of hypertension liver-fire hyperactivity syndrome based on disease-syndrome combined animal models of hypertension, selecting the related molecules by mutual information method, depicting the related molecular relationship using graph model, constructing hypertension liver-fire hyperactivity syndrome identification model using the decision tree method. With the intervention of clearing liver-fire formulas，to prove and illustrate the internal molecular biological mechanism of hypertension with liver-fire hyperactivity syndrome,provid objective basis for diagnosis and therapeutic evaluation of hypertension liver-fire hyperactivity syndrome, and put forward new method and intervention targets in hypertension treatment.

英文关键词： Essential Hypertension;Data mining;Biological mechanism