Robust Multi-Model Subset Selection

Modern datasets in biology and chemistry are often characterized by the presence of a large number of variables and outlying samples due to measurement errors or rare biological and chemical profiles. To handle the characteristics of such datasets we introduce a method to learn a robust ensemble comprised of a small number of sparse, diverse and robust models, the first of its kind in the literature. The degree to which the models are sparse, diverse and resistant to data contamination is driven directly by the data based on a cross-validation criterion. We establish the finite-sample breakdown of the ensembles and the models that comprise them, and we develop a tailored computing algorithm to learn the ensembles by leveraging recent developments in l0 optimization. Our extensive numerical experiments on synthetic and artificially contaminated real datasets from bioinformatics and cheminformatics demonstrate the competitive advantage of our method over state-of-the-art sparse and robust methods. We also demonstrate the applicability of our proposal on a cardiac allograft vasculopathy dataset.