We explore the use of machine learning techniques to remove the response of large volume $\gamma$-ray detectors from experimental spectra. Segmented $\gamma$-ray total absorption spectrometers (TAS) allow for the simultaneous measurement of individual $\gamma$-ray energy (E$_\gamma$) and total excitation energy (E$_x$). Analysis of TAS detector data is complicated by the fact that the E$_x$ and E$_\gamma$ quantities are correlated, and therefore, techniques that simply unfold using E$_x$ and E$_\gamma$ response functions independently are not as accurate. In this work, we investigate the use of conditional generative adversarial networks (cGANs) to simultaneously unfold $E_{x}$ and $E_{\gamma}$ data in TAS detectors. Specifically, we employ a \texttt{Pix2Pix} cGAN, a generative modeling technique based on recent advances in deep learning, to treat \rawmatrix~ matrix unfolding as an image-to-image translation problem. We present results for simulated and experimental matrices of single-$\gamma$ and double-$\gamma$ decay cascades. Our model demonstrates characterization capabilities within detector resolution limits for upwards of 93% of simulated test cases.
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