3D indoor layout synthesis is crucial for creating virtual environments. Traditional methods struggle with generalization due to fixed datasets. While recent LLM and VLM-based approaches offer improved semantic richness, they often lack robust and flexible refinement, resulting in suboptimal layouts. We develop DisCo-Layout, a novel framework that disentangles and coordinates physical and semantic refinement. For independent refinement, our Semantic Refinement Tool (SRT) corrects abstract object relationships, while the Physical Refinement Tool (PRT) resolves concrete spatial issues via a grid-matching algorithm. For collaborative refinement, a multi-agent framework intelligently orchestrates these tools, featuring a planner for placement rules, a designer for initial layouts, and an evaluator for assessment. Experiments demonstrate DisCo-Layout's state-of-the-art performance, generating realistic, coherent, and generalizable 3D indoor layouts. Our code will be publicly available.
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