We consider a generalized collision channel model for general multi-user communication systems, an extension of Massey and Mathys' collision channel without feedback for multiple access communications. In our model, there are multiple transmitters and receivers sharing the same communication channel. The transmitters are not synchronized and arbitrary time offsets between transmitters and receivers are assumed. A ``collision" occurs if two or more packets from different transmitters partially or completely overlap at a receiver. Our model includes the original collision channel as a special case. This paper focuses on reliable throughputs that are approachable for arbitrary time offsets. We consider both slot-synchronized and non-synchronized cases and characterize their reliable throughput regions for the generalized collision channel model. These two regions are proven to coincide. Moreover, it is shown that the protocol sequences constructed for multiple access communication remain ``throughput optimal" in the generalized collision channel model. We also identify the protocol sequences that can approach the outer boundary of the reliable throughput region.
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