Analysis of Tomographic Reconstruction of 2D Images using the Distribution of Unknown Projection Angles

It is well known that a band-limited signal can be reconstructed from its uniformly spaced samples if the sampling rate is sufficiently high. More recently, it has been proved that one can reconstruct a 1D band-limited signal even if the exact sample locations are unknown, but given just the distribution of the sample locations and their ordering in 1D. In this work, we extend the analytical bounds on the reconstruction error in such scenarios for quasi-bandlimited signals. We also prove that the method for such a reconstruction is resilient to a certain proportion of errors in the specification of the sample location ordering. We then express the problem of tomographic reconstruction of 2D images from 1D Radon projections under unknown angles with known angle distribution, as a special case for reconstruction of quasi-bandlimited signals from samples at unknown locations with known distribution. Building upon our theoretical background, we present asymptotic bounds for 2D quasi-bandlimited image reconstruction from 1D Radon projections in the unknown angles setting, which commonly occurs in cryo-electron microscopy (cryo-EM). To the best of our knowledge, this is the first piece of work to perform such an analysis for 2D cryo-EM, even though the associated reconstruction algorithms have been known for a long time.