In this paper, we focus on the design of binary constant-weight codes that admit low-complexity encoding and decoding algorithms, and that have size as a power of $2$. We construct a family of $(n=2^\ell, M=2^k, d=2)$ constant-weight codes ${\cal C}[\ell, r]$ parameterized by integers $\ell \geq 3$ and $1 \leq r \leq \lfloor \frac{\ell+3}{4} \rfloor$, by encoding information in the gaps between successive $1$'s of a vector. The code has weight $w = \ell$ and combinatorial dimension $k$ that scales quadratically with $\ell$. The encoding time is linear in the input size $k$, and the decoding time is poly-logarithmic in the input size $n$, discounting the linear time spent on parsing the input. Encoding and decoding algorithms of similar codes known in either information-theoretic or combinatorial literature require computation of large number of binomial coefficients. Our algorithms fully eliminate the need to evaluate binomial coefficients. While the code has a natural price to pay in $k$, it performs fairly well against the information-theoretic upper bound $\lfloor \log_2 {n \choose w} \rfloor$. When $\ell =3$, the code is optimal achieving the upper bound; when $\ell=4$, it is one bit away from the upper bound, and as $\ell$ grows it is order-optimal in the sense that the ratio of $k$ with its upper bound becomes a constant $\frac{11}{16}$ when $r=\lfloor \frac{\ell+3}{4} \rfloor$. With the same or even lower complexity, we derive new codes permitting a wider range of parameters by modifying ${\cal C}[\ell, r]$ in two different ways. The code derived using the first approach has the same blocklength $n=2^\ell$, but weight $w$ is allowed to vary from $\ell-1$ to $1$. In the second approach, the weight remains fixed as $w = \ell$, but the blocklength is reduced to $n=2^\ell - 2^r +1$. For certain selected values of parameters, these modified codes have an optimal $k$.
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