The credibility revolution advances the use of research designs that permit identification and estimation of causal effects. However, understanding which mechanisms produce measured causal effects remains a challenge. A dominant current approach to the quantitative evaluation of mechanisms relies on the detection of heterogeneous treatment effects with respect to pre-treatment covariates. This paper develops a framework to understand when the existence of such heterogeneous treatment effects can support inferences about the activation of a mechanism. We show first that this design cannot provide evidence of mechanism activation without an additional, generally implicit, assumption. Further, even when this assumption is satisfied, if a measured outcome is produced by a non-linear transformation of a directly-affected outcome of theoretical interest, heterogeneous treatment effects are not informative of mechanism activation. We provide novel guidance for interpretation and research design in light of these findings.
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