Interface problems depict many fundamental physical phenomena and widely apply in the engineering. However, it is challenging to develop efficient fully decoupled numerical methods for solving degenerate interface problems in which the coefficient of a PDE is discontinuous and greater than or equal to zero on the interface. The main motivation in this paper is to construct fully decoupled numerical methods for solving nonlinear degenerate interface problems with ``double singularities". An efficient fully decoupled numerical method is proposed for nonlinear degenerate interface problems. The scheme combines deep neural network on the singular subdomain with finite difference method on the regular subdomain. The key of the new approach is to split nonlinear degenerate partial differential equation with interface into two independent boundary value problems based on deep learning. The outstanding advantages of the proposed schemes are that not only the convergence order of the degenerate interface problems on whole domain is determined by the finite difference scheme on the regular subdomain, but also can calculate $\mathbf{VERY}$ $\mathbf{BIG}$ jump ratio(such as $10^{12}:1$ or $1:10^{12}$) for the interface problems including degenerate and non-degenerate cases. The expansion of the solutions does not contains any undetermined parameters in the numerical method. In this way, two independent nonlinear systems are constructed in other subdomains and can be computed in parallel. The flexibility, accuracy and efficiency of the methods are validated from various experiments in both 1D and 2D. Specially, not only our method is suitable for solving degenerate interface case, but also for non-degenerate interface case. Some application examples with complicated multi-connected and sharp edge interface examples including degenerate and nondegenerate cases are also presented.
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