Supervised Multi-Modal Fission Learning

Learning from multimodal datasets can leverage complementary information and improve performance in prediction tasks. A commonly used strategy to account for feature correlations in high-dimensional datasets is the latent variable approach. Several latent variable methods have been proposed for multimodal datasets. However, these methods either focus on extracting the shared component across all modalities or on extracting both a shared component and individual components specific to each modality. To address this gap, we propose a Multi-Modal Fission Learning (MMFL) model that simultaneously identifies globally joint, partially joint, and individual components underlying the features of multimodal datasets. Unlike existing latent variable methods, MMFL uses supervision from the response variable to identify predictive latent components and has a natural extension for incorporating incomplete multimodal data. Through simulation studies, we demonstrate that MMFL outperforms various existing multimodal algorithms in both complete and incomplete modality settings. We applied MMFL to a real-world case study for early prediction of Alzheimers Disease using multimodal neuroimaging and genomics data from the Alzheimers Disease Neuroimaging Initiative (ADNI) dataset. MMFL provided more accurate predictions and better insights into within- and across-modality correlations compared to existing methods.