Quantum combs play a vital role in characterizing and transforming quantum processes, with wide-ranging applications in quantum information processing. However, obtaining the explicit quantum circuit for the desired quantum comb remains a challenging problem. We propose PQComb, a novel framework that employs parameterized quantum circuits (PQCs) or quantum neural networks to harness the full potential of quantum combs for diverse quantum process transformation tasks. This method is well-suited for near-term quantum devices and can be applied to various tasks in quantum machine learning. As a notable application, we present two streamlined protocols for the time-reversal simulation of unknown qubit unitary evolutions, reducing the ancilla qubit overhead from six to three compared to the previous best-known method. We also extend PQComb to solve the problems of qutrit unitary transformation and channel discrimination. Furthermore, we demonstrate the hardware efficiency and robustness of our qubit unitary inversion protocol under realistic noise simulations of IBM-Q superconducting quantum hardware, yielding a significant improvement in average similarity over the previous protocol under practical regimes. PQComb's versatility and potential for broader applications in quantum machine learning pave the way for more efficient and practical solutions to complex quantum tasks.
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