超声造影对兔肝VX2肿瘤转移机制与肿瘤原位消融靶点相关性的研究

项目名称： 超声造影对兔肝VX2肿瘤转移机制与肿瘤原位消融靶点相关性的研究

项目编号： No.81471680

项目类型： 面上项目

立项/批准年度： 2015

项目学科： 医药、卫生

项目作者： 李志艳

作者单位： 中国人民解放军总医院

项目金额： 72万元

中文摘要： 肝癌是消化系统最常见的恶性肿瘤之一，发病率和病死率高。肝癌发病较隐匿，发现时多为晚期，并常合并微小转移灶，可行手术切除者不足1/4。随着原位灭活及消融技术的发展，给肝癌患者提供更多的救治机会。肝癌的早期诊断和生长方式的全面评估对选择合适的治疗方案、延长生存期及改善预后具有重要意义。肝肿瘤微血管生成、微血管密度与肿瘤浸润转移和复发的相关性是近年来肿瘤浸润、转移机制研究的热点，但肝组织的另一重要循环途径-淋巴循环（肝肿瘤的淋巴管生成和肝肿瘤淋巴侵袭与转移关系）的研究尚未取得突破性进展。本研究拟应用超声造影技术探索肝肿瘤血行及淋巴管生长的差异性，构建超声造影参数与肝肿瘤淋巴转移机制的关系，筛选出血行和淋巴侵袭及转移的特异性超声造影指标，进而根据血行及淋巴侵袭及转移的不同机制指导原位灭活消融方案并确定消融靶点，从而为肝癌不同转移机制的侵袭和转移情况提供客观的诊断依据，实现优化肝肿瘤治疗策略的目标。

中文关键词： 超声造影；肝细胞肝癌；射频消融；淋巴道转移；微血管密度

英文摘要： Liver cancer is the most common malignant tumors of the digestive system , with a high morbidity and mortality.Liver cancer is latent, and found mostly late. As often associated with micrometastases, surgical resection is less than 1/4. With the development of in situ inactivation and ablation techniques, patients with liver cancer have more opportunities of being treatment. Early diagnosis and comprehensive assessment of the growth pattern of the liver cancer are important for choosing the right treatment, prolong survival and improve prognosis. Liver tumor angiogenesis and microvessel density are correlated with tumor metastasis and recurrence, that it is a research focus of transfer mechanism and tumor invasion in recent years. But another important way circulation of liver tissue has not yet made a breakthrough,which the research of lymphatic circulation include liver tumor lymphangiogenesis and lymphatic invasion and metastasis of liver cancer relationship. In this study, using contrast enhanced ultrasound techniques to explore the differences of the liver tumor blood and lymphatic growth, and build relationship CEUS parameters and mechanisms of lymph metastasis, and selecte the specific indicators of blood and lymphatic metastasis. Further according to the different mechanisms of blood and lymphatic invasion and metastasis, to develop in situ inactivation ablation program, and determine the ablation target.Thus,to provide an objective basis for the diagnosis of the invasion and metastasis of various transfer mechanisms, and achieve goals of optimize liver cancer treatment strategies.

英文关键词： Contrast-enhanced ultrasonography;Hepatocellular carcinoma;Radiofrequency ablation;Lymph node metastases;Microvessel density