甲壳素晶须复合可降解网络型聚酯生物弹性体的制备、微观结构及力学性能调控

项目名称： 甲壳素晶须复合可降解网络型聚酯生物弹性体的制备、微观结构及力学性能调控

项目编号： No.51303024

项目类型： 青年科学基金项目

立项/批准年度： 2014

项目学科： 一般工业技术

项目作者： 吉亚丽

作者单位： 东华大学

项目金额： 25万元

中文摘要： 组织工程生物材料在相容性研究方面虽然取得了很大进展，但与组织器官的力学性能适应性仍是需要解决的关键问题。可降解网络型聚酯生物弹性体－聚柠檬酸二醇酯 （PDC）因降解均匀、强度损失线性、形状保持率高、与人体许多软组织力学性能相匹配，以及结构的可设计性和性能的可调节性成为软组织工程最理想的材料之一。但是，近期申请者在对PDC的研究中发现，PDC的力学性能主要由单体种类和交联程度调节，在通过增加交联程度来提高材料强度和模量的同时，不可避免会损失材料的断裂伸长。本项目通过原位纳米复合技术将甲壳素纳米晶须引入到PDC生物弹性体当中，通过其在弹性体基体中形成三维渗漏网络结构，来提高材料的强度与模量，而由交联程度调控材料的断裂伸长，从而实现力学性能的可控调节。利用各种分析测试手段建立纳米复合材料微观结构与力学性能之间的关系，并利用粒子析出法制备纳米复合物生物支架,初步评价其在组织工程领域的应用价值。

中文关键词： 甲壳素；纳米晶须；纳米复合；增强机理；生物弹性体

英文摘要： Biomaterials for tissue engineering have made much progress in biocompatibility, but its mechanical adaptability to the tissues of body is still a key problem to be resolved. Biodegradable polyester elastomer-poly(diol citrate) (PDC) is a kind of ideal biomaterial for soft tissue scaffold. It possesses even degedation rate, linear loss of strength, high resistance to deformation, matchable mechanical properties to target tissues, designed structure and regulated mechanical properties. While, the mechanical properties of PDC can only be regulated by the monomers category and the crosslink degree. It was found the elongation at break would inevitably decrease when the strength and modulus were increased by improving the crosslink degree. In this program, the chitin whiskers will be incorporated into poly(1,8-octanediol citrate) (POC) matrix to form nanocomposites by in situ nanocomposite technique. In this system, the strength and modulus will be adjusted by chitin whiskers, which are expected to form 3D percolation structure in the matrix, and the elongation at break will be adjusted by the crosslink degree. Thus, the effective regulation of mechanical properties of POC elastomer can be realized. The relationship between the microstructures and the mechanical properties of nanocomposites will be sett up by relati

英文关键词： chitin；nanocrystal；nanocomposite；reinforcing mechanism；bioelastomer