基于脂质组学的高脂血症中医证候生物标志物研究

项目名称： 基于脂质组学的高脂血症中医证候生物标志物研究

项目编号： No.81202619

项目类型： 青年科学基金项目

立项/批准年度： 2013

项目学科： 医学八处

项目作者： 朴胜华

作者单位： 广东药学院

项目金额： 23万元

中文摘要： 高脂血症为临床常见多发病，危害大，病机复杂，证候表现多样。那么，其复杂证候背后，体内脂质代谢情况是否也存在不同？针对高脂血症这一疾病，因其证候不同，治则组方也不同，但能取得同样疗效，这种同病异治现象及理论科学内涵是什么？为回答上述问题，我们首次将脂质组学技术用于高脂血症主要证候研究。脂质组学属于代谢组学分支，其概念于2003年提出，已广泛用于疾病药物研究和疾病诊断。前期我们对高脂血症主要证候之一肝郁脾虚证开展了脂质组学研究，发现其4个脂质标记物。提示高脂血症其他证候之间也应该存在脂质代谢的不同。然而，其不同的具体表现到底是什么？是否有规律可循？是否有其确切脂质标记物？尚未可知。源此，本项目拟进一步开展高脂血症主要证候脂质组学研究，发现其不同中医证候脂质代谢规律；寻找其脂质生物标记物，为建立方证相应的调脂方药提供新靶点；也为高脂血症中医证候实质研究提供客观依据，揭示中医同病异治理论科学内涵。

中文关键词： 高脂血症；中医证候；脂质组学；生物标记物；

英文摘要： Hyperlipidemia is a common disease with high morbidity,risk,complicated pathogenesis,and various clinical manifestations.Is there any changes in lipid metabolism with different manifestations in vivo? As it's noted that,different priscription can get similar effect according to the manifestations of hyperlipidemia in TCM.Then,what's the scientific essence implied in the phenomenon about heterotherapy for homopathy? In order to find the answers of these issues, lipidomics ,for the first time, has been introduced into the study of manifestations about hyperlipidemia.Lipidomics, a branch of metabolomics, has been proposed as a new conception in 2003 and widely used in drug research and disease diagnosis. Our previous studies have found 4 lipidic biomarkers of Gan Yu Pi Xu"syndrome ,which is one of the major syndrome of hyperlipidemia.These findings give us clues that there is difference in lipid metabolism of different syndromes.Then, what's the difference? Is there any regularities and lipidic biomakers.Based on this, this project intends to further study the lipidolomics of syndromes of hyperlipidemia, find the regularity of lipid metabolism with different syndrome of hyperlipidemia,and search the lipidic biomarkers. This research will provide new targets for establishing and developing formula and drugs with imp

英文关键词： hyperlipemia；TCM syndrome；lipidomics；biomarker；