参苓白术散对仔猪断奶腹泻肠道菌群区系变化关系的干预机制研究

项目名称： 参苓白术散对仔猪断奶腹泻肠道菌群区系变化关系的干预机制研究

项目编号： No.31472232

项目类型： 面上项目

立项/批准年度： 2015

项目学科： 水产学、兽医学

项目作者： 郭世宁

作者单位： 华南农业大学

项目金额： 83万元

中文摘要： 断奶仔猪腹泻是目前养猪业中亟待解决的一个重要课题，但是对其与肠道菌群的关系缺乏研究。通过选择断奶前后日龄相近的各组仔猪观察小肠形态学变化，明确腹泻对肠道黏膜的损伤；采用宏基因组学分析技术，了解仔猪断奶腹泻与肠道微生物的变化规律和特征，验证腹泻影响肠道菌群区系的变化这一假设；通过肠道内容物中参苓白术散主要成分的检测了解肠道菌群对参苓白术散的相互影响。研究结果有望揭示腹泻与肠道菌群的相关性以及参苓白术散对腹泻疾病的防控机制，为中药药理学和人类研发新的防治腹泻疾病的药物提供理论依据。

中文关键词： 干预机制；断奶仔猪；腹泻；肠道菌群；参苓白术散

英文摘要： Weaning piglets diarrhea is an important subject to be solved in the pig industry，but it lacks of research on the relationship between the weaning piglets diarrhea and intestinal flora. In order to know the diarrhea damages of intestinal mucosa, the intestinal morphology is observed by chosen the weaning or no weaned piglet. The macro genomics analysis technology is used to understand the piglet weaning diarrhea and change rules and characteristics of gut microbes and verify the assumption of diarrhea influence the change of intestinal flora. In order to know the role of intestinal flora on shenling baizhu powder, the shenling baizhu powder's ingredients is tested by the intestinal contents. The results hope to show the correlation between the diarrhea and intestinal flora, and to explain the mechanism of shenling baizhu powder to Intervene diarrhea, and to provide the theoretical basis for traditional Chinese medicine pharmacology and new drug research.

英文关键词： intervention mechanism;weaning piglet;diarrhea;intestinal flora;shenling baizhu powder