基于瞬态空化效应的低频超声皮肤增透机制研究

项目名称： 基于瞬态空化效应的低频超声皮肤增透机制研究

项目编号： No.11204210

项目类型： 青年科学基金项目

立项/批准年度： 2013

项目学科： 物理学I

项目作者： 于海霞

作者单位： 天津大学

项目金额： 30万元

中文摘要： 为了解决低频超声皮肤增透技术中实现组织液透皮抽取和药物透皮导入的定量化问题，进而推广低频超声皮肤增透技术的临床应用，项目原创性的提出了一种研究低频超声皮肤增透微观机制的方法。该方法通过微流控芯片技术和光电精密测试测量方法的有机结合，实现微米尺度内空化气泡瞬时变化过程的高速、高分辨率、精确、直接观测，并辅之以多物理场耦合的有限元和边界元分析技术，来研究和建立低频超声皮肤增透机制的理论模型。项目的研究内容包括：（1）观测不同超声作用条件下被测表面附近，单个瞬态空化气泡崩溃的动力学过程，辨识瞬态空化方式，确定空化位置；（2）测量和分析瞬态空化方式和空化位置，与伴随瞬态空化发生的压强和温度变化之间的关系；（3）测量和分析超声作用条件和皮肤表面特性对皮肤表面瞬态空化分布的影响；（4）对低频超声皮肤增透机制进行理论分析、数值模拟和实验验证。

中文关键词： 低频超声；皮肤增透；瞬态空化；微流控芯片；光电精密测试

英文摘要： In order to solve the dosage control problems in transdermal interstitial fluid extraction and transdermal drug delivery by low-frequency sonophoresis, and extend the clinical application of low-frequency ultrasound-based technology for skin permeabilization, a method to study the microscopic mechanism of skin permeabilization by low-frequency sonophoresis is innovatively proposed in this project. In this method, the high speed, high resolution, high precision, and direct observation of the transient variation process of cavitation bubble in micron scale will be carried out by combining the microfluidic chip technology with highly precise photoelectric measurement methods. In addition, multiphysics coupling analysis will be performed utilizing finite element method and boundary element method to study and build the theoretical model of the mechanism of skin permeabilization by low-frequency sonophoresis. The contents of this project include: (1) observe the dynamic process of a single transient cavitation bubble collapsing near the measured surface under different ultrasound conditions, identify the style of transient cavitation, and determine the position of cavitation; (2) measure and analyze the relationship between the transient cavitation style, position, and variations of pressure and temperature caused by

英文关键词： low-frequency ultrasound；skin permeabilization；transient cavitation；microfluidic chip；precise photoelectric measurement