Quantum computers progress toward outperforming classical supercomputers, but quantum errors remain their primary obstacle. The key to overcoming errors on near-term devices has emerged through the field of quantum error mitigation, enabling improved accuracy at the cost of additional run time. Here, through experiments on state-of-the-art quantum computers using up to 100 qubits, we demonstrate that without sacrificing accuracy machine learning for quantum error mitigation (ML-QEM) drastically reduces the cost of mitigation. We benchmark ML-QEM using a variety of machine learning models -- linear regression, random forests, multi-layer perceptrons, and graph neural networks -- on diverse classes of quantum circuits, over increasingly complex device-noise profiles, under interpolation and extrapolation, and in both numerics and experiments. These tests employ the popular digital zero-noise extrapolation method as an added reference. Finally, we propose a path toward scalable mitigation by using ML-QEM to mimic traditional mitigation methods with superior runtime efficiency. Our results show that classical machine learning can extend the reach and practicality of quantum error mitigation by reducing its overheads and highlight its broader potential for practical quantum computations.
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