In 2017, J. B. Carlisle has proposed a method for fraud detection in randomized controlled trials based on a comparison of reported baseline data between treatment groups. While Carlisle has only used the method for continuous variables, some authors have recently employed a naive adaption of the method for dichotomous variables. We explain why such adaptation leads to p-values that are wrong by orders of magnitude and we make a simple concrete proposal for correction of the method.
翻译:2017年,J.B.Carlisle根据对各治疗组之间所报告的基线数据的比较,提出了在随机控制的试验中发现欺诈的方法。虽然Carlisle只使用了连续变量的方法,但一些作者最近对二分变量的方法进行了天真的调整。我们解释了为什么这种调整导致按数量级排列错误的p值,我们提出了纠正方法的简单具体建议。