A novel image space formalism of Fourier domain interpolation neural networks for noise propagation analysis

Purpose: To develop an image space formalism of multi-layer convolutional neural networks (CNNs) for Fourier domain interpolation in MRI reconstructions and analytically estimate noise propagation during CNN inference. Theory and Methods: Nonlinear activations in the Fourier domain (also known as k-space) using complex-valued Rectifier Linear Units are expressed as elementwise multiplication with activation masks. This operation is transformed into a convolution in the image space. After network training in k-space, this approach provides an algebraic expression for the derivative of the reconstructed image with respect to the aliased coil images, which serve as the input tensors to the network in the image space. This allows the variance in the network inference to be estimated analytically and to be used to describe noise characteristics. Monte-Carlo simulations and numerical approaches based on auto-differentiation were used for validation. The framework was tested on retrospectively undersampled invivo brain images. Results: Inferences conducted in the image domain are quasi-identical to inferences in the k-space, underlined by corresponding quantitative metrics. Noise variance maps obtained from the analytical expression correspond with those obtained via Monte-Carlo simulations, as well as via an auto-differentiation approach. The noise resilience is well characterized, as in the case of classical Parallel Imaging. Komolgorov-Smirnov tests demonstrate Gaussian distributions of voxel magnitudes in variance maps obtained via Monte-Carlo simulations. Conclusion: The quasi-equivalent image space formalism for neural networks for k-space interpolation enables fast and accurate description of the noise characteristics during CNN inference, analogous to geometry-factor maps in traditional parallel imaging methods.