The group testing problem is a canonical inference task where one seeks to identify $k$ infected individuals out of a population of $n$ people, based on the outcomes of $m$ group tests. Of particular interest is the case of Bernoulli group testing (BGT), where each individual participates in each test independently and with a fixed probability. BGT is known to be an ``information-theoretically'' optimal design, as there exists a decoder that can identify with high probability as $n$ grows the infected individuals using $m^*=\log_2 \binom{n}{k}$ BGT tests, which is the minimum required number of tests among \emph{all} group testing designs. An important open question in the field is if a polynomial-time decoder exists for BGT which succeeds also with $m^*$ samples. In a recent paper (Iliopoulos, Zadik COLT '21) some evidence was presented (but no proof) that a simple low-temperature MCMC method could succeed. The evidence was based on a first-moment (or ``annealed'') analysis of the landscape, as well as simulations that show the MCMC success for $n \approx 1000s$. In this work, we prove that, despite the intriguing success in simulations for small $n$, the class of MCMC methods proposed in previous work for BGT with $m^*$ samples takes super-polynomial-in-$n$ time to identify the infected individuals, when $k=n^{\alpha}$ for $\alpha \in (0,1)$ small enough. Towards obtaining our results, we establish the tight max-satisfiability thresholds of the random $k$-set cover problem, a result of potentially independent interest in the study of random constraint satisfaction problems.
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