Complexes and cohomology, traditionally central to topology, have emerged as fundamental tools across applied mathematics and the sciences. This survey explores their roles in diverse areas, from partial differential equations and continuum mechanics to reformulations of the Einstein equations and network theory. Motivated by advances in compatible and structure-preserving discretisation such as Finite Element Exterior Calculus (FEEC), we examine how differential complexes encode critical properties such as existence, uniqueness, stability and rigidity of solutions to differential equations. We demonstrate that various fundamental concepts and models in solid and fluid mechanics are essentially formulated in terms of differential complexes.
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