It has been found that the effect of childhood trauma (CT) exposure may pass on to the next generation. Scientists have hypothesized that the association between CT exposure and placental-fetal stress physiology is the mechanism. A study was conducted to examine the hypothesis. To examine the association between CT exposure and placental corticotrophin-releasing hormone (pCRH), linear mixed effect model and hierarchical Bayesian linear model were constructed. In Bayesian inference, by providing conditionally conjugate priors, Gibbs sampler was used to draw MCMC samples. Piecewise linear mixed effect model was conducted in order to adjust to the dramatic change of pCRH at around week 20 into pregnancy. Pearson residual, QQ, ACF and trace plots were used to justify the model adequacy. Likelihood ratio test and DIC were utilized to model selection. The association between CT exposure and pCRH during pregnancy is obvious. The effect of CT exposure on pCRH varies dramatically over gestational age. Women with one childhood trauma would experience 11.9% higher in pCRH towards the end of pregnancy than those without childhood trauma. The increase rate of pCRH after week 20 is almost four-fold larger than that before week 20. Frequentist and Bayesian inference produce similar results. The findings support the hypothesis that the effect of CT exposure on pCRH over GA exists. The effect changes dramatically at around week 20 into pregnancy.
翻译:已经发现,儿童创伤(CT)接触的影响可能会传到下一代,科学家们假设接触CT与胎盘内应激反应生理联系是这个机制。进行了一项研究以审查这一假设。为了检查接触CT与胎盘内胆碱酯酶分泌激素(PCRH)、线性混合效应模型和巴伊西亚等级线性模型之间的联系,在巴伊西亚的推断中,通过提供有条件的同质前科,使用Gibbs采样器来提取MCMCM样本。进行了分线性线性混合效应模型,以适应大约20周内PCRHH的急剧变化。利用了Pearson残留物、 ⁇ 、ACF和痕迹图图来证明该模型是否适当。利用了类似比率测试和DIC来进行模型选择。在怀孕期间接触CT和PCRHA之间的关联在妊娠年龄上有很大差异。患有一种童年创伤的妇女,在PCRHF20周内会经历11.9%的怀孕后会经历更深。在PCRHF的一周内几乎更接近一周内产生类似的结果。