We propose a nonparametric, kernel-based joint estimator for conditional mean and covariance matrices in large unbalanced panels. Our estimator, with proven consistency and finite-sample guarantees, is applied to a comprehensive panel of monthly US stock excess returns from 1962 to 2021, conditioned on macroeconomic and firm-specific covariates. The estimator captures time-varying cross-sectional dependencies effectively, demonstrating robust statistical performance. In asset pricing, it generates conditional mean-variance efficient portfolios with out-of-sample Sharpe ratios that substantially exceed those of equal-weighted benchmarks.
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