The Internet of Things (IoT) and wireless generations have been evolving simultaneously for the past few decades. Built upon wireless communication and sensing technologies, IoT networks are usually evaluated based on metrics that measure the device ability to sense information and effectively share it with the network, which makes Integrated Sensing and Communication (ISAC) a pivotal candidate for the sixth-generation (6G) IoT standards. This paper reveals several innovative aspects of ISAC from an IoT perspective in 6G, empowering various modern IoT use cases and key technology enablers. Moreover, we address the challenges and future potential of ISAC-enabled IoT, including synergies with Reconfigurable Intelligent Surfaces (RIS), Artificial Intelligence (AI), and key updates of ISAC-IoT in 6G standardization. Furthermore, several evolutionary concepts are introduced to open future research in 6G ISAC-IoT, including the interplay with Non-Terrestrial Networks (NTN) and Orthogonal Time-Frequency Space (OTFS) modulation.
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