In the world reference context, though mixed reality have been an emerging methodology for several years, only today technological and scientific advances have made them suitable to revolutionize in the industry and among people's daily life through the provision of enhanced functionalities and improved services. This systematic review provides the state-of-the-art applications and utilities of the Microsoft HoloLens 2 by reviewing the related papers during 2022-2023. Focusing on the potential that this technology has in providing digitally supported simulations and other utilities, highlighting the potential and limitations of the HoloLens 2-based innovative solutions and also bringing focus to emerging research topics, such as telemedicine, remote control and optimization of direct volume rendering.
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