This paper presents a secure and versatile sampling-based verification protocol, Proof of Sampling (PoSP) protocol, suitable for a wide range of decentralized applications. Our protocol has a unique Nash Equilibrium in pure strategies, which compels rational participants to act honestly, thus fortifying the network's integrity. This can be achieved with manageable computational overhead. When applied to decentralized inference for AI applications, we design spML based on PoSP protocol, which ingeniously amalgamates the strengths of optimistic fraud proof and zero knowledge proof based approaches, the foremost approaches in the domain at present. Moreover, the PoSP protocol can be effectively utilized for designing verification mechanisms within Actively Validated Services (AVS) in EigenLayer and Layer 2 solutions, further broadening its applicability. This innovative approach not only enhances the security and efficiency of decentralized systems but also paves the way for a new generation of scalable and reliable decentralized applications.
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