几类典型基因调控网络的混合建模及动力学分析

项目名称： 几类典型基因调控网络的混合建模及动力学分析

项目编号： No.61304151

项目类型： 青年科学基金项目

立项/批准年度： 2014

项目学科： 自动化技术、计算机技术

项目作者： 王沛

作者单位： 河南大学

项目金额： 25万元

中文摘要： 系统生物学是国家中长期科技规划中面向国家重大战略需求的基础研究领域，又是基金委十二五发展规划纲要中信息科学部优先部署发展的领域。基因调控网络是系统生物学研究的一类很重要的复杂生物网络。但是，目前主要集中于简单环路的离散布尔模型及微分方程建模研究，由于网络层次基因调控网络自身的结构复杂性及微分方程模型的复杂性，复杂基因调控网络的定量建模及分析还很少。基于复杂网络及动力系统理论，本项目旨在研究几类典型基因调控网络的混合布尔和微分方程建模及动力学分析，包括简单环路、整合环路、多细胞耦合环路及一般的大中型调控网络；通过对若干从简单到复杂的基因网络的建模分析，推动系统层次的系统生物学研究，为量化的阐明复杂的基因调控网络的刺激-响应关系及设计原理提供思路。相关研究有助于在基因组层次上系统的理解细胞及生命活动，解释疾病的发生、发展以及治疗，对网络医学、个性化医学和合成生物学等具有重要理论价值和应用前景。

中文关键词： 系统生物学；基因调控网络；网络模体；关键节点识别；双稳系统

英文摘要： Systems biology is included in the major strategic needs of the country's basic research fields in the national medium and long-term science and technology planning, and it is also treated as the prior to the deployment of development areas in department of information science in the CSC twelfth five-year development plan. Gene regulatory networks are very important complex biological networks in the field of systems biology. However, current investigations mainly focus on discrete Boolean modeling and differential equation modeling of simple circuits,few models and quantitative analysis results have been reported on network-level gene regulatory networks, which are mainly due to its structural complexicity and the complexicity of differential equation models of network-level gene regulatory networks. Based on complex networks and dynamical system theory, this project aims to investigate the hybrid discrete boolean and differential equation modeling and dynamical analysis of several representative gene regulatory networks, which include simple circuits、intergrated circuits、coupled multi-cellular circuits as well as some general medium-sized and large-sized gene regulatory networks;Through the modeling and dynamical analysis of serveral simple-to-complex gene networks, this project expects to promote system-leve

英文关键词： Systems biology；Gene regulatory network；Network motif；Vital node identification；Bistable system