基于微细结构的虚拟人体肾脏药物代谢仿真研究

项目名称： 基于微细结构的虚拟人体肾脏药物代谢仿真研究

项目编号： No.60873170

项目类型： 面上项目

立项/批准年度： 2009

项目学科： 金属学与金属工艺

项目作者： 陈戈

作者单位： 中国海洋大学

项目金额： 33万元

中文摘要： 本项目利用国际上对人体数字图像采集数据以日趋成熟的基础，结合虚拟现实技术和数据可视化技术以及体感交互和视觉体验的研究基础，对人体肾脏结构进行基于真实肾脏数字切片图像的分割、配准以及三维可视化重建和虚拟现实交互。进而对虚拟人体肾脏进行生理功能仿真和视觉交互体验研究。基于生理微细结构水平的虚拟现实技术与人体断面扫描虚拟人数据库之间有很强的互补性。利用虚拟现实技术，对基于药物肾脏内排泄仿真生理模型进行探索，对用虚拟肾脏能否代替真实人体药物代谢试验提出假设并通过实验进行验证，以期弥补传统药物动力学研究以经验公式为主的不足。 本项目研究开发了虚拟现实人体肾脏交互软件，大大提高了传统虚拟肾脏重建的效率，并优化了快速医学图像分割算法，对虚拟肾脏的三维数据进行可视化编辑与修改，采用了体感交互技术进行沉浸式体验，通过模型仿真与数值仿真结合进行药物排泄的仿真模拟。并以国际合作的形式开展虚拟人与虚拟器官结合的视觉体验研究。

中文关键词： 虚拟肾脏;微细结构;仿真计算;药代动力学

英文摘要： It is understood that the technology for visible human image collecting is getting matures. Based on the previous research of virtual reality, data visualization, motion interaction and visual experience, the sliced images in VKH visible human dataset are segmented, registered and 3D reconstructed for VR interaction. On the basis of that, this project deals with the study of the simulation for human kidney physiological functions and the interaction for visual experience. It has very strong complementary that the VR technology on physiological microstructure level and the section sliced visible human dataset. This project explores the simulation methods and models of drug metabolism in virtual human kidney by using VR technology and probes if the virtual kidney is available for drug trails instead of real human. In this project, an interactive virtual human kidney software has been developed. The efficiency of traditional method for human organs recontruction has been enhanced especially for kidney model. A optimized algorithm for fast medical image segmentation has been approached. An interactive editable kidney model has been established. It can be manipulated by motion capture and immersive experience using Kinect. The simulation for drug motablism is conducted by model simulations and numerical simulations. The research of the integration for virtual human and virtual organs were began to do by international coorperation.

英文关键词： virtual kidney;microstructure;simulation;pharmacokinetics