项目名称: 医用有机表面复合微纳结构的超疏水及细菌抑制特性研究
项目编号: No.11504369
项目类型: 青年科学基金项目
立项/批准年度: 2016
项目学科: 数理科学和化学
项目作者: 徐佳
作者单位: 中国科学院长春光学精密机械与物理研究所
项目金额: 24万元
中文摘要: 医疗领域中,常用的细菌抑制方法主要以化学抑菌、生物抑菌和物理抑菌为主。但化学及生物试剂的使用,将极大地改变操作及测试环境的属性、降低仪器和设备的使用效率并会造成工作环境的污染。物理抑菌虽然解决了化学及生物抑菌中所带来的问题,但传统物理抑菌材料及薄膜的制备只能针对于微米或纳米中的某一个量级。对于具有不同尺寸、形态及生物特性的细菌,单一的表面结构降低了材料及薄膜抑菌的多样性和有效性,限制了抑菌材料及薄膜的应用范围和领域。本项目针对此问题,采用软光刻制备技术,在大尺寸有机聚合物表面制备微米级周期性结构,并利用三相界面上内弯液面引起的毛细力,在微米结构顶部形成具有纳米级特征尺寸的表面结构。通过兼具微米与纳米尺寸的复合结构,实现材料表面对不同形态、尺寸及种类细菌的抑制,解决了传统物理抑菌材料及薄膜中单一表面结构分布对细菌抑制的选择性和针对性,真正实现了多种类、高效率、大面积的细菌抑制效能。
中文关键词: 微纳制备技术;纳米光刻;周期性结构;人工微结构;物理方法
英文摘要: In the field of medicine, the method of the bacteriostatic is based on the chemical antibacterial, biological antibacterial and physical antimicrobial. But the operating and test environment will greatly be change and the working efficiency will be reduced due to the chemistry and biological reagent. The problem from the chemical and biological antibacterial is solved by the physical antimicrobial, but the micro and nano scales are separated during the processing of fabricating the traditional physical antimicrobial films. The single surface structures reduced the variety and validity of the antimicrobial film and resist the application field and range. For this problem, the periodic micro structures of the polymers are fabricated by the soft-lithography, and the capillary is used to fabricate the nano structures on the micro structures. It is achieved that the surface structures of the micro-nano scales is used to resist the bacteria with the different shapes, sizes and varieties for the applications of the various, high efficiency and large area antibacterial.
英文关键词: micro-nano fabrication techniques;nano lithography;periodic structures;artificial micro structures;physical method