弥散张量成像及白质纤维束示踪技术对视放射的显像及其最佳参数的比较研究

项目名称： 弥散张量成像及白质纤维束示踪技术对视放射的显像及其最佳参数的比较研究

项目编号： No.30800349

项目类型： 青年科学基金项目

立项/批准年度： 2009

项目学科： 金属学与金属工艺

项目作者： 陈晓雷

作者单位： 中山大学

项目金额： 21万元

中文摘要： 在使用弥散张量成像（DTI）技术对脑干的主要纤维束进行显像的研究中，我们发现该技术可以准确显示出锥体束和感觉传导束。那么，能否使用DTI 技术来对视放射纤维束进行显像？纤维束重建的各向异性值（FA）参数是什么？其准确性和可靠性如何？为此，我们设计了这个前瞻性的对比试验，希望通过改进的平面回波水抑制成像（EPI FLAIR）序列扫描有颞叶胶质瘤的研究对象，然后重建视放射前支（Meyer 袢），并最终通过统计学分析将DTI 显示出的纤维束变化与术前后视野变化相关联，从而证实DTI 技术能否准确、可靠地显示出视放射。在进行涉及视放射的有创性操作时，此研究将为我们提供全新的思路和方法来观察病理状态下的视放射，有助于在围手术期制订个体化的手术方案，减少手术并发症，改善患者术后生存质量，还将为开发新的纤维束神经导航技术提供理论和技术基础。

中文关键词： 弥散张量成像；纤维束示踪；视放射

英文摘要： In our pilot study, we have proved the feasibility and the validity for Diffusion Tensor Imaging(DTI) based Fiber Tracking(FT) to depict the major fiber tracts in brainstem. Then, is it feasible to depict the optic radiation with DTI based FT? How is the accuracy and validity? In this prospective study, we sought to relate the status of optic radiation, assessed by pre- and post-operative DTI based FT, to the extent of visual field defect(VFD) following temporal lobe glioma removal with statistical analysis(ROC curve analysis). By doing this, we try to determine the changes in the size and course of optic radiation due to surgical resection, and to address first, whether DTI based FT can precisely depict optic radiation; second, what is the validity of DTI based FT for the depiction of optic radiation; and third, what can be the best strategy to minimize the injury of optic radiation during temporal lobe epilepsy surgery? This study will offer us a new method to "visualize" the optic radiation under pathological status. With the help of this technique, we can make individualized surgical plan. And we anticipate that visualizing the optic radiation by fiber tracking navigation in the surgical field may decrease post-operative complication rate, thus increase the post-operative life quality of the patients. It will also offer us the theoretical and technical proof for develoing new DTI based fiber tract navigation methods.

英文关键词： Diffusion tensor imaging; fiber tracking; optic radiation